ChloroquineV1, Main, Exploration, bibRecord, 003146

The liver plays an important role in the regulation of somatostatin-14 in the rat

Identifieur interne : 003146 ( Main/Exploration ); précédent : 003145; suivant : 003147

The liver plays an important role in the regulation of somatostatin-14 in the rat

Auteurs : Steven E. Raper [États-Unis] ; Piyush C. Kothary [États-Unis] ; Norihiro Kokudo [États-Unis] ; John Delvalle [États-Unis] ; Frederic E. Eckhauser [États-Unis]

Source :

The American Journal of Surgery [ 0002-9610 ] ; 1991.

RBID : ISTEX:85B46696C65A0B1139CD624F24EE5FA2E617C856

English descriptors

Teeft :
- American journal, Bile, Bile canalicular bile flow, Biliary, Biliary excretion, Biliary radioactivity, Biliary secretion, Biol chem, Brain microvessels, Chloroquine, Cholecystokinin peptides, Degradation, Direct pathway, Enterohepatic circulation, Epidermal growth factor, Glucose release, Hepatic, Hepatic processing, Hepatic radioactivity, Hepatic uptake, Hplc, Hplc analysis, Intracellular, Intracellular processing, Intraportal, Intraportal injection, Lysosomal, Lysosomal degradation, Lysosomotropic agents, Metabolism, Other organ, Other organs, Pathway, Peptide, Peptide hormones, Portal blood, Preliminary evidence, Radioactive label, Radioactivity, Secretion, Somatostatin, Somatostatin analogues, Srif, Statistical analysis, Surgery volume, Time course, Tracer, Uptake, Weight basis.

Abstract

Abstract: Since little is known about the in vivo disposition of circulating somatostatin-14 (SRIF-14), we examined hepatic processing of SRIF-14 in the rat. Three minutes after the intraportal injection of iodine 125 (125I)-labeled SRIF-14, 16.0 ± 2.0% of the injected dose is localized to the liver. In the presence of unlabeled SRIF-14, hepatic uptake can be decreased by 68%. Five minutes after the intraportal injection of 125I-SRIF-14, 9.5 ± 1.4% of the tracer is localized to the liver, more than any other organ tested. Serial collections of bile reveal peak radioactivity at between 10 and 20 minutes. Simultaneous administration of unlabeled SRIF-14 decreases biliary radioactivity by 40%. HPLC analysis of radioactive bile reveals a chromatographic profile similar to that of intact SRIF and is 73% immunoprecipitable by an anti-SRIF antibody. Pretreatment with chloroquine, a lysosomal enzyme inhibitor, does not significantly decrease biliary radioactivity. We conclude that the data are consistent with saturable hepatic uptake and predominantly nonlysosomal transcellular transport.

Url:

https://api.istex.fr/ark:/67375/6H6-6WFR6LC7-1/fulltext.pdf

DOI: 10.1016/0002-9610(91)90382-N

Affiliations:

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Le document en format XML

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<front><div type="abstract" xml:lang="en">Abstract: Since little is known about the in vivo disposition of circulating somatostatin-14 (SRIF-14), we examined hepatic processing of SRIF-14 in the rat. Three minutes after the intraportal injection of iodine 125 (125I)-labeled SRIF-14, 16.0 ± 2.0% of the injected dose is localized to the liver. In the presence of unlabeled SRIF-14, hepatic uptake can be decreased by 68%. Five minutes after the intraportal injection of 125I-SRIF-14, 9.5 ± 1.4% of the tracer is localized to the liver, more than any other organ tested. Serial collections of bile reveal peak radioactivity at between 10 and 20 minutes. Simultaneous administration of unlabeled SRIF-14 decreases biliary radioactivity by 40%. HPLC analysis of radioactive bile reveals a chromatographic profile similar to that of intact SRIF and is 73% immunoprecipitable by an anti-SRIF antibody. Pretreatment with chloroquine, a lysosomal enzyme inhibitor, does not significantly decrease biliary radioactivity. We conclude that the data are consistent with saturable hepatic uptake and predominantly nonlysosomal transcellular transport.</div>
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The liver plays an important role in the regulation of somatostatin-14 in the rat

The liver plays an important role in the regulation of somatostatin-14 in the rat

Source :

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

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